Question

An autosomal genetic disorder called 'cri-du-chat' is caused due to

• A. Deletion
• B. Duplication
• C. Non-disjunction
• D. Mutation

Answer 1

Answer: (A)

Deletion

Depending upon the type of chromosome affected (sex or autosome) the genetic disorder is autosomal or sex-linked. The autosomal disorder is dominant or recessive depending upon whether one allele or both the all are affected. 'CRI-du-chat' syndrome also known as cat cry syndrome is caused due to monosomy (deletion) of the small arm (p) of chromosome number 5. The symptoms of the disorder are retarded growth, microcephaly, hypotonia etc. Therefore the disorder is autosomal caused due to deletion.

Thus the correct answer is option A.