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B
Non-sense mutation
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C
Variation
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D
Intron
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Solution
The correct option is B Non-sense mutation In genetics, a point nonsense mutation is a point mutation in a sequence of DNA that results in a premature stop codon, or a point nonsense codon in the transcribed mRNA and formed usually nonfunctional protein product. the functional effect of a point nonsense mutation depends on the location of the stop codon within the coding DNA. Hence, an immature stop codon leads to a nonsense mutation in a particular protein.