Question

Anaphase Promoting Complex (APC) is a protein complex that tags some proteins involved in cell cycle for degradation. If APC is non-functional in a human cell, which of the following is an expected outcome?

• A. Chromosomes will be fragmented
• B. Chromosomes will not segregate
• C. Recombination of chromosomes
• D. Absence of chromosome condensation

Answer 1

The correct option is B Chromosomes will not segregate

Anaphase promoting Complex (APC) helps in binding specific proteins and degrades it. This in turn initiates the cell to enter from metaphase to anaphase.

APC protein complexes tags specific protein to the sister chromatids and degrades them. This in turn helps sister chromatids to separate and helps the cell to enter anaphase stage.

If APC is non-functional then it will not initiate the protein degradations. As a result the sister chromatids will not segregate. Therefore option 'b' is the correct answer.