______ are the smallest unit of matter that can take part in a chemical reaction.

Molecules

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Compounds

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Atoms

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Electrons

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Solution

The correct option is D Atoms
Dalton's atomic theory states that atoms are the smallest unit of matter that can participate in a chemical reaction. Chemical reactions involve the combination, separation, or rearrangement of atoms, but atoms are neither created, destroyed, divided into parts, or converted into atoms of any other kind.
Option $C$ is correct.

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Which is the smallest particle of an element that can take part in a chemical reaction?

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