Arrange the changes during muscle activation as they happen
1. Calcium level increases.
2. Calcium level decreases.
3. Troponin and tropomyosin move to allow myosin to bind to actin.
4. The cross bridge cycle begins.
1, 3, 4, 2.
Brain decides that you want to flex your elbow and sends a signal from the CNS down to the peripheral motor neurons, which then innervate the muscles of our body.
1. ⇒ When the signal reaches the presynaptic terminal, acetylcholine is released into the motor end plate, which binds to receptors on the presynaptic membrane and creates an action potential which spreads throughout the muscle fibre, causing release of calcium from the sarcoplasmic cisternae into the sarcolemma of the muscle.
2. ⇒ Later to relax the level of calcium ions is decreased and the mechanism retreats.
3. ⇒These calcium ions then attach themselves to the Troponin C component of Troponin.
4. ⇒ These calcium ions then attach themselves to the Troponin C component of Troponin. This causes the troponin to change and push the tropomyosin off of the actin filaments thus unmasking the sites for binding of the myosin. so increase in the level is the first step in muscle contraction.