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Assertion [A]: Only a boy child could be born with the substitution of glutamic acid by valine on the 6th position of haemoglobin chain.

Reason [R]: The gene for the above mutation occurs in Y chromosome.

A
Both A and R are true and R is the correct explanation of A.
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B
Both A and R are true but R is not the correct explanation of A.
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C
A is true but R is false.
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D
Both A and R are false.
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Solution

The correct option is C Both A and R are false.
  • Sickle-cell anaemia arises due to gene mutation in the autosomes. It doesn't affect either of the sex chromosomes (X or Y).
  • It can be transmitted from parents to the offspring when both the partners are carriers for the gene or are suffering from the disease. Only homozygous individuals show the diseased phenotype.
  • In sickle-cell anaemia the RBCs become sickle-shaped. It is caused due to the replacement of glutamic acid by valine at the 6th position of the haemoglobin chain.

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