Question

Assertion :A tumour of adrenal cortex may cause Addison's disease. Reason: This happens due to over secretion of cortisol by a tumour.

• A. Both Assertion and Reason are correct and Reason is the correct explanation for Assertion
• B. Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion
• C. Assertion is correct but Reason is incorrect
• D. Both Assertion and Reason are incorrect

Answer 1

The correct option is D Both Assertion and Reason are incorrect

Destruction of adrenal cortex by diseases like tuberculosis produces Addison's disease, due to the deficiency of glucocorticoids and mineralocorticoids which are secreted by the adrenal cortex region zone fasciculata and zona glomerulosa respectively. Symptoms of Addison's disease include a bronze-like pigmentation of the skin, low blood sugar, low plasma $N{a}^{+}$, high plasma $K^{+}$, increased urinary $N{a}^{+}$, nausea, vomiting and diarrhoea. Cortisol is a glucocorticoid which regulates the metabolisms of carbohydrates, fats and proteins. A tumour of the adrenal cortex may secret too much cortisol to produce Cushing's syndrome. High blood sugar, the appearance of sugar in the urine, obesity, wasting of limb muscles, rise in plasma$N{a}^{+}$, fall in plasma $K^{+}$, a rise in blood volume and high blood pressure are observed in the patient suffering from Cushing's syndrome.

So the correct answer is 'Both Assertion and Reason are incorrect'.