Assertion: Enzymes have active sites that hold substrate molecule for a chemical reaction.
Reason: Drugs compete with natural substrate by attaching covalently to the active site of enzyme.
Assertion
⮚ Enzymes do have active sites that hold substrate molecules for a certain chemical reaction in a living organism.
⮚ This active site of enzymes usually hold the substrate molecule at a suitable orientation so that the substrate can interact effectively.
⮚ Substrates bind to the active sites through the ionic bond, H-bonding, van der Waals interaction, or dipole-dipole interaction.
So, assertion is correct.
Hence, assertion is a correct statement, and the reason is a wrong statement.