Assertion :Histamine is involved in allergic and inflammatory reactions Reason: Histamine is vasodilator
A
Both Assertion and Reason are correct and Reason is the correct explanation for Assertion
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B
Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion
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C
Assertion is correct but Reason is incorrect
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D
Both Assertion and Reason are incorrect
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Solution
The correct option is A Both Assertion and Reason are correct and Reason is the correct explanation for Assertion Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. It is involved in the inflammatory response and has a central role as a mediator of itching. Histamine is a vasodilator and mediates increased vascular permeability (blood flow) in the area of the body where allergen affected. This results in inflammation and further stimulation of chemical mediators of inflammation which mediates inflammatory response.
So, the correct answer is 'Both Assertion and Reason are correct and Reason is the correct explanation for Assertion'.