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Question

Assertion :In TCA cycle, isomerisation of citric acid into isocitric acid is done by change in CO2 (COO) position. Reason: Isocitric acid is more stable than citric Acid.

A
Both Assertion and Reason are correct and Reason is the correct explanation for Assertion
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B
Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion
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C
Assertion is correct but Reason is incorrect
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D
Both Assertion and Reason are incorrect
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Solution

The correct option is D Both Assertion and Reason are incorrect
In TCA cycle or Krebs cycle, isomerization of citric acid into isocitric acid occurs due to the removal of one water molecule first and then an addition of another water molecule back which results in the conversion of citrate into its isomer, isocitrate. Hence, the assertion is incorrect.
Isocitrate is not stable than citrate as isocitrate loses a molecule of CO2 and forms a five-carbon compound which gets oxidized. Hence, the reason is also incorrect.
So, the correct answer is 'Both Assertion and Reason are incorrect'.

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