Assertion :Ischaemic kidney produces hypertension. Reason: Such kidney liberates renin.

Both assertion and reason are correct and reason is the correct explanation for assertion.

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Both assertion and reason are correct but reason is not the correct explanation for assertion.

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Assertion is correct but reason is incorrect.

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Both assertion and reason are incorrect.

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Solution

The correct option is A Both assertion and reason are correct and reason is the correct explanation for assertion.
Inadequate blood flow (hypoperfusion) to the kidneys due to partial constriction of the main renal artery results into ischaemic kidneys causing reduction in glomerular filtration rate or loss of renal parenchyma. Ischaemic kidneys produces a marked and permanent hypertension, which is not due to excretory insufficiency of the kidney or due to an increase in blood volume or cardiac output, nor is it produced through a nervous mechanism. Renal ischaemia results in hypertension through a humoral mechanism. The ischaemic kidney secretes renin. This protein is an enzyme, which acts on a blood globulin (hypertensinogen) and gives rise to a substance (hypertensin) that has a direct vasoconstrictor action causing hypertension.
So, the correct answer is 'Both assertion and reason are correct and reason is the correct explanation for assertion.'

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