Question

Assertion: Non-competitive inhibitor inhibits the catalytic activity of enzyme by binding with its active site.

Reason: Non-competitive inhibitor changes the shape of the active site in such a way that substrate can’t recognise it.

• A. Both assertion and reason are wrong statements
• B. Assertion is correct statement reason is wrong statement
• C. Assertion and reason both are correct, and reason explains the assertion
• D. Assertion is wrong statement reason is correct statement
• E. Assertion and reason both are correct statement, but reason does not explain assertion

Answer 1

The correct option is D Assertion is wrong statement reason is correct statement

Assertion

Non-competitive inhibitors do not bind to the enzyme’s active site. These bind to a different site of enzyme which is called allosteric site.

So, assertion is wrong.

Reason

Non-competitive inhibitors change the shape of the active site of the enzyme in such a way that the substrate will not be able to recognise it.

So, reason is correct.

Hence, assertion is wrong statement reason is correct statement.

So correct answer is option $\left(E\right)$