Question

Assertion :Persons suffering from haemophilia fail to produce blood clotting factor VIII. Reason: Prothrombin producing platelets in such persons are found in very low concentration.

• A. Both Assertion and Reason are correct and Reason is the correct explanation for Assertion.
• B. Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion.
• C. Assertion is correct but Reason is incorrect.
• D. Both Assertion and Reason are incorrect.

Answer 1

The correct option is C Assertion is correct but Reason is incorrect.

Sufferers from haemophilia experience repeated episodes of severe and prolonged bleeding at any site, with little evidence of trauma. Recurrent bleeding into joints is common, causing severe pain and, in the long term, cartilage is damaged. The two main forms of haemophilia differ only in the clotting factor involved; the clinical picture in both is identical.
Haemophilia A: In this disease, factor VIII is abnormal and is less biologically active.
Haemophilia B (Christmas disease): This is the less common sex-linked genetic haemorrhagic disease. Factor IX is deficient, resulting in the deficiency of thromboplastin.
Von Willebrand's disease: In this disease, a deficiency in the von Willebrand factor causes low levels of factor VIII. As the inheritance is not sex-linked, haemorrhages due to defective clotting occur equally in males and females.

Therefore, the correct answer is option C.