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Question

Assertion :The -As=As- linkage present in arsphenamine (a sulpha drugs) resemles the -N=N- linkage present is azo dyes. Reason: The first antibacterial agent, prontosil resembles in structure to the compound salvarsan.

A
Both Assertion and Reason are correct and Reason is the correct explanation for Assertion
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B
Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion
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C
Assertion is correct but Reason is incorrect
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D
Both Assertion and Reason are incorrect
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Solution

The correct option is B Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion
  • Sulfa drug, also called sulfonamide, any member of a group of synthetic antibiotics containing the sulfanilamide molecular structure. Sulfa drugs were the first chemical substances systematically used to treat and prevent bacterial infections in humans.
  • Paul Ehlrich a German bacteriologist was investigating Arsenic based structures in order to produce less toxic substances for the treatment of syphilis. He developed the medicine, arsphenamine, known as salvarsan.Salvarsan is not a sulpha drug.
  • Ehrlich was working on azodyes. The –As = As– linkage present in arsphenamine resembles the –N = N – linkage present in azodyes in the sense that arsenic atom is present in place of nitrogen.
  • He also succeeded in preparing the first effective antibacterial agent, prontosil, which resembles in structure to the compound, salvarsan.
  • Hence,both Assertion and reason are correct but reason is not correct explanation for assertion.

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