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Question
Assertion :The RNAi can be introduced in an organism by insection of gene encoding complementary RNA only. Reason: These are no methods by which in vitro synthesised complementary RNA can be inserted in an organism to induce RNAi (RNA interference).
Assertion :The RNAi can be introduced in an organism by insection of gene encoding complementary RNA only. Reason: These are no methods by which in vitro synthesised complementary RNA can be inserted in an organism to induce RNAi (RNA interference).
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Solution
The correct option is D Both Assertion and Reason are incorrect
RNAi (RNA interference) takes place in all eukaryotic organisms as a
method of cellular defense. This method involves silencing of a specific
mRNA due to a complementary dsRNA molecule that binds to and prevents
translation of the mRNA. There are two methods to induce RNA
interference in any organism. The complementary RNA can be synthesised
in vitro and then annealed to produce dsRNA and inserted into cells or
the cells are genetically modified to produce the two complementary RNA
strands or duplex form in vivo by transcription. However, the first
method i.e., insertion of in vitro synthesised complementary RNA
inhabits target gene expression for only 4-6 days and their
re-introduction is required. But the second method i.e. the DNA vector
construct once transferred into the cells will keep on generating RNA
interference and thereby, cause a permanent inhibition of the damage.
So, the correct answer is 'Both Assertion and Reason are incorrect'.
RNAi (RNA interference) takes place in all eukaryotic organisms as a
method of cellular defense. This method involves silencing of a specific
mRNA due to a complementary dsRNA molecule that binds to and prevents
translation of the mRNA. There are two methods to induce RNA
interference in any organism. The complementary RNA can be synthesised
in vitro and then annealed to produce dsRNA and inserted into cells or
the cells are genetically modified to produce the two complementary RNA
strands or duplex form in vivo by transcription. However, the first
method i.e., insertion of in vitro synthesised complementary RNA
inhabits target gene expression for only 4-6 days and their
re-introduction is required. But the second method i.e. the DNA vector
construct once transferred into the cells will keep on generating RNA
interference and thereby, cause a permanent inhibition of the damage.
So, the correct answer is 'Both Assertion and Reason are incorrect'.
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