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Question

At what age should the gene isolated from a bone marrow producing ADA be introduced to the patient to permanently cure ADA deficiency?

A
Teenage
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B
Fetus just before birth
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C
Pre-puberty childhood
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D
Embryonic stage
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Solution

The correct option is D Embryonic stage
When the ADA gene is introduced inside the embryonic cells it gives rise to haematopoietic cells which produce lymphocytes without genetic defect throughout the individual's life span. Hence, it can be regarded as a permanent cure.
At any other stage of life, the cure will not be permanent as the bone marrow with the genetic defect would have already formed.

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