Question

B-lymphocytes differentiate and mature in

• A. Bone marrow
• B. Bursa of Fabricus
• C. Thymus
• D. Both A and B

Answer 1

The correct option is D Both A and B

• B cell activation occurs in the secondary lymphoid organs, such as the spleen and lymph nodes.
• After B cells mature in the bone marrow, they migrate through the blood secondary lymphoid organs to which receive a constant supply of antigen through circulating lymph.
• In birds, the bursa of Fabricius is the site of hematopoiesis, a specialized organ that is necessary for B cell development in birds.
• Hence, B-lymphocytes differentiate and mature in Bone marrow and Bursa of Fabricius.
• So, the correct answer is 'Both A and B'.