Blackening of exposed urine is a metabolic disorder due to

Phenylalanine

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Tyrosine

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Homogentisic acid

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Valine replacing glutamic acid

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Glutamic acid replacing valine

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Solution

The correct option is C Homogentisic acid
Homogentisic acid and its oxidized form alkapton are excreted in the urine, giving it an unusually dark color. The accumulating homogentisic acid causes damage to cartilage (ochronosis, leading to osteoarthritis) and heart valves, as well as precipitating as kidney stones and stones in other organs.
So, the correct answer is 'Homogentisic acid'.

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β

In sickle cell anaemia, glutamic acid is replaced by valine. Which one of the following triplets codes valine?

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