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Question

Blood carries CO2 mainly in which form?

A
HbCO2
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B
Carbonic acid
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C
NaCO2
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D
HbCO2 and carbon monoxide.
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Solution

The correct option is A HbCO2

When carbon dioxide binds to haemoglobin, carbaminohaemoglobin is formed, lowering haemoglobin's affinity for oxygen via the Bohr effect. In the absence of oxygen, unbound haemoglobin molecules have a greater chance of becoming carbaminohaemoglobin. The Haldane effect relates to the increased affinity of de-oxygenated haemoglobin for H+: offloading of oxygen to the tissues thus results in increased affinity of the haemoglobin for carbon dioxide which can then be transported to the lung for removal. Carbaminohaemoglobin has a distinctive blue colour that may contribute to the dark red colour of deoxygenated venous blood (compared to bright, saturated red of oxygenated arterial blood), blue colour of veins and the purplish or bluish colour of tissues inhypoxia.

Haemoglobin can bind to four molecules of carbon dioxide. The carbon dioxide molecules form a carbamate with the four terminal-amine groups of the four protein chains in the deoxy form of the molecule. Thus, one haemoglobin molecule can transport four carbon dioxide molecules back to the lungs, where they are released when the molecule changes back to the oxyhemoglobin form.

Hence, the correct answer is 'HbCO2'


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