Blood haemoglobin has high affinity for

C O_{2}

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O_{2}

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Solution

The correct option is B CO
Carbon monoxide has 210 times greater affinity for haemoglobin than oxygen. A small environmental concentration will thus cause toxic levels of carboxyhaemoglobin. After the carbon monoxide has selectively bound to haemoglobin, the oxygen-haemoglobin dissociation curve of the remaining oxyhaemoglobin shifts to the left, reducing oxygen release. Cellular uptake of oxygen is blocked by binding of carbon monoxide with mitochondrial cytochrome.

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