The correct option is C Low O2 and high CO2 concentration
At high oxygen concentrations oxyhaemoglobin is formed and at low oxygen concentrations oxyhaemoglobin dissociates to haemoglobin and oxygen. The presence of carbon dioxide helps the release of oxygen from haemoglobin, this is known as the Bohr effect. Carbon dioxide is a waste product of respiration and its concentration is high in the respiring cell. So, in the metabolically active cells increased carbon dioxide causes release of oxygen from oxyhemoglobin.