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Standard XII
Biology
Pedigree Chart of X-Linked Recessive Disorders
Can a girl ge...
Question
Can a girl get hemophilia?
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Solution
Hemophilia:
Hemophilia is an X-chromosome-linked recessive disorder. It is a blood-clotting disease where the clotting process is delayed.
Yes
, girls can have hemophilia but this case is rare.
It is an X-linked recessive disease, caused by the mutation in the X chromosome.
In girls, there are two copies of X chromosomes so a mutation in both X chromosomes will cause the disease.
Mutation in one X chromosome will result in a carrier state.
As mutation in both X chromosomes is rare so girls rarely have this disease they become carriers as usually mutation happens in one X chromosome.
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A heterozygous carrier of the hemophilia allele in woman marries with a man who is affected with hemophilia. What will be the expected percentage of hemophilia in their female children?
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John, a male hemophiliac, marries Jane, a normal woman, and together they have four children, two boys (Mark and Mike) and two girls (Molly and Mary). None of the children display the symptoms of hemophilia. Mark, Mike, Molly, and Mary all marry normal individuals and have children. None of Mark's or Mike's children, male or female, display symptoms of hemophilia, but the sons of Molly and Mary all display symptoms of hemophilia while the daughters of Molly and Mary do not. W
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Hemophilia is a hereditary disease carried by
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Pedigree Chart of X-Linked Recessive Disorders
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