Inertia is unrelated to friction. Imagine a rail car sitting still on a track. Could you start it moving by pushing it yourself? Probably not, but this is because of of static friction between the wheels and the track. If it had inertia alone you could move it though maybe only at an insensibly low speed. As you pushed it would gradually speed up. The reason it would speed up gradually is because of it's inertial mass. Newton's second law is formulated as f = ma. The f term is the amount of force you exert and the a term is it's acceleration. Because in the case of of a rail car m is large a will be small.
Friction is different than acceleration because it acts as a force countering the force you exert on on an object and can change depending on what the object is made of and how fast it is going. For instance if the track and the wheel were made of different substances the friction between them could increase or decrease. Also if instead of pushing the car by hand, you hitched it to a locomotive it would start rolling with a jerk. This jerk happens because the static friction when the car is standing still is higher than the rolling friction. Inertial mass is a far more fundamental quantity and cannot be easily made to be vary the way friction can be.