Cancer cells have lost the property of contact inhibition.
Why_____?

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Solution

Contact inhibition is an improtant anticancer mechanism that arrests the cell division when cells reach higher densities.
Contact inhibition arrests the cell growth when cells come in contact with each other. So, the normal cells stop proliferating. Contact inhibition is lost in cancer cells. Cancer cells do not arrest their growth but it continues to proliferate and piles up on the top of each other forming a multilayered foci. This growth arrest is signaled by membrane proteins and mediated by the elevated levels of p27Kip1 cyclin-dependent kinase inhibitor. This process arrests the cells from growth in the G1 phase of the cell cycle.

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Similar questions

Read the following statements regarding "Regulation of cell division” and identify the incorrect statement(s).

I. Regulation of cell division is a natural and an inherited property of a cell.

II. Contact inhibition is a method of regulation of cell division.

III. Regulation of cell division can also be inhibited by anchorage dependence of a cell.

IV. Anchorage dependence and contact inhibition increase the growth of cells and ensure that high cell density is maintained at all times.

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