Question

Catalytic group of active site weakens substrate bonds by

• A. Channel energy
• B. Electrophilic changes
• C. Nucleophilic changes
• D. Both B and C

Answer 1

Answer: (D)

Both B and C

Electrophile is the molecule which has tendency to attract electron while a neucleophile has tendency to lose electron. Attractive and buttressing groups of the active site form a comple­mentary structure when the substrate approaches the enzyme and catalytic group comes in close proximity of the bond of the substrate to be broken. The catalytic site puts a strain on the enzyme substrate bond through electrophilic and nucleophilic forces which leads to formation of product.

So, the correct answer is option D.