The correct option is A Pyrogens
Pyrogens are substances that induce fever. These can be internal (endogenous) or external (exogenous) to the body. The bacterial substance, lipopolysaccharide or LPS, present in the cell wall of some bacteria is an example of an exogenous pyrogen.
Histamine is an organic nitrogenous compound involved in local immune responses.
Toxins are compounds producing toxins. These toxins interfere with the metabolism and make the cell wall porous.
Pathogens are infectious agents that activate the immune response.
So, the correct answer is option A.