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B
Pancreas
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C
Liver
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D
Spleen
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Solution
The correct option is C Liver Slightly less than half of the cholesterol in the body derives from biosynthesis de novo. Biosynthesis in the liver accounts for approximately 10% and in the intestines approximately 15%, of the amount produced each day. The cholesterol biosynthesis pathway involves enzymes that are in the cytoplasm, microsomes (ER), and peroxisomes. Synthesis of cholesterol, like that of most biological lipids, begins from the two-carbon acetate group of acetyl-CoA. Cholesterol synthesis does not occurs in pancreas, spleen and Brunner's gland.