The correct option is
B Give up
“Hand over” means to pass the responsibility to someone else.
“Help out” means to provide aid when in need.
“Give in” means to cease fighting, to accept defeat.
“Transmit” means to transfer something
“Give up” means to cease to make an effort or to cease control over something.
“Make over” means to complete change over
Hence option D is the correct answer because it is the correct meaning of the given phrase.