The correct option is
D Despise
'Look down upon' means to show contempt for or to regard oneself as superior to someone or something and thus act in a haughty or snobbish manner. Option A is the answer that is closest in meaning to the given phrase. 'Despise' means to feel contempt or a deep repugnance for.
Options B, C, D and E are incorrect because 'see things in perspective' means to think about a situation or problem in a wise and reasonable way, 'appreciate' means to recognize how good someone or something is and to value him/her/it, 'deprecate' means to express disapproval of or to belittle and 'depreciate' means to (cause something to) lose value, especially over time.