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Question

Choose the options associated with Leber hereditary optic neuropathy.

A
Arises due to defect in the nuclear DNA
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B
Arises due to defect in mitochondrial DNA
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C
Is inherited from both father and mother
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D
(a) and (c) above.
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Solution

The correct option is B Arises due to defect in mitochondrial DNA
Leber hereditary optic neuropathy is a mitochondrial disorder which leads to vision loss. This happens due to mutation in the mitochondrial DNA. Since mitochondria are contributed by the ovum alone, mitochondrial disorders are inherited from the mother only.

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