The correct option is A sacred
The word 'profane' refers to being secular or non-religious.
Option A, sacred refers to something connected with God.
Option B, pure refers to something unadulterated and uncontaminated.
Option C, profound refers to something very great or intense.
Option D, high refers to something great in rank, status or importance.
Thus, according to the meaning, the word 'sacred' is the opposite of the word 'profane'.