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B Nucleic acid, histone and non-histone proteins
Structure of a nucleosome
Nucleosomes are submicroscopic units of chromatin which are about
11 nm in diameter and
5.7−6 nm in height.
Each nucleosome consists of a core of
8 histone molecules around which the DNA strand is tightly wrapped in
2 circles.
Adjacent nucleosomes are connected by a linker DNA. A typical nucleosome consists of
200 base pairs of DNA.
Nucleosomes on DNA form a ‘beads on string’ appearance, where the nucleosome forms the beads and the linker DNA is seen as the string.
Chromatin
Repeating units of nucleosomes form the chromatin which is further packaged to form the chromatin fibres.Packaging of chromatin at higher levels requires the involvement of non-histone proteins to stabilise the structure.
Thus chromatins consist of nucleic acids, histone molecules and non-histone proteins.