The correct option is B Hormones
Chromatophores are irregularly shaped pigment-containing cells. Melanophores are a type of chromophores. These melanophores are present on the skin of a frog with melanin dispersed throughout the branches of the cells. This effect is produced by a hormone called MSH, i.e., melanocyte stimulating hormone (MSH). When the pigment retreats to the centre of the cells, the skin lightens.
So, the correct answer is option A.