Question

Chronic allograft rejection results primarily from the actions of what effector cell type?

• A. Activated macrophages
• B. Helper T lymphocytes
• C. Cytotoxic T lymphocytes
• D. Dendritic cells

Answer 1

The correct option is C Cytotoxic T lymphocytes

The transplant of an organ or tissue from one individual to another of the same species with a different genotype is called a allograft.
Transplant rejection occurs when transplanted tissue is rejected by the recipient's immune system.
Effector cells are the relatively short-lived activated cells that defend the body in an immune response.
Allograft rejection occurs primarily due to the actions of cytotoxic T cells. T-helper cells promote this reaction but are not the effector cells.
Both macrophages and dendritic cells may present antigen that promotes the immune response, but the key effector cells are cytotoxic T cells.