Colchicine causes

Aneuploidy

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Inhibition of spindle fibre development

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Centromeres to divide

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Polyploidy

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Solution

The correct option is B Inhibition of spindle fibre development
A mitotic inhibitor is a drug that inhibits mitosis, or cell division. These drugs disrupt microtubules, which are structures that pull the cell apart when it divides. Mitotic inhibitors are derived from natural substances such as plant alkaloids, and prevent cells from undergoing mitosis by disrupting microtubule polymerization, thus preventing cancerous growth. Colchicine and griseofulvin are mitotic inhibitors used in the treatment of gout and toenail fungus, respectively.

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