Question

Colchicine interferes in

• A. Spindle organisation
• B. DNA replication
• C. Chromosome condensation
• D. Polyploidy

Answer 1

Answer: (A)

Spindle organisation

Alkaloid colchicine is called as the mitotic poison. It binds to tubulin, unit of microtubules which form the spindle apparatus in mitosis. thus inhibiting the micro tubules to assemble to form spindle fibers. Therefore, alkaloid colchicine interferes with mitosis and chromosome segregation and the cell division is arrested at metaphase in presence of colchicine.

So, the correct answer is 'Spindle organisation'.