Colchicine is a drug known to stop the formation of spindle fibres. what will happen to when dividing cells in a cell culture are treated with colchicines

Cells will die

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Cells will not enter into cell cycle

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Cells will enter into cell cycle but get arrested in metaphase

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Cells will complete the cell cycle

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Solution

The correct option is C Cells will enter into cell cycle but get arrested in metaphase
Since colchicines inhibits growth of spindle fibres and the major role of spindle fibre is to pull the chromosomes to the poles during anaphase. So, colchicines treated cells will enter in cell cycle but will be arrested at metaphase.

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Colchicine is a chemical that stops chromatids from separating during mitosis.

Which phase will the cell reach and then stop dividing?

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