The correct option is B Both John and his wife are doctors.
Cumulative conjunctions are used for merely adding one statement to another.
Option C is correct: "Both... and" simply add together these two sentences and lay equal emphasis on facts stated in the two statements.
Option A: "Or" offers choice between two statements. Hence, "or" is not an example of cumulative conjunction.
Option B is incorrect: "John and his wife" are two subjects in the sentence, hence, "are" should be used with them.
Option D is incorrect: "But" shows contrast between the two statement while joining them. Hence, it is not an example of cumulative conjunction.