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Question

Connecting link between respiration (TCA cycle) and protein synthesis is

A
Citric acid
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B
α- ketoglutaric acid
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C
Succinic acid
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D
Fumaric acid
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Solution

The correct option is A α- ketoglutaric acid
The Tricarboxylic Acid (TCA) cycle, also known as the Kreb's cycle provides for the various intermediates that result in the formation of bio-molecules which are then used for other metabolic pathways. The oxaloacetate and the alpha-ketoglutarate are used in the synthesis of amino acids, and these amino-acids take part in protein synthesis.
A. Citric acid is used in the formation of fatty acids and sterols.
B. alpha-ketoglutaric acid is used in the synthesis of glutamate that forms the amino-acids.
C. Succinic acid is used in the formation of porphyrins.
D. Fumaric acid forms the malic acid which is then converted to the oxaloacetic acid. Oxaloacetic acid is used in the synthesis of amino acids.
Hence, the correct answer is 'alpha-ketoglutaric acid'

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