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Question
Considering that we have four nucleotides A,G, C, T. The number of base substitutions that can occur in the amino acid codons are
Considering that we have four nucleotides A,G, C, T. The number of base substitutions that can occur in the amino acid codons are
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Solution
The correct option is B 1098
Base substitution is the replacement of a base pair which can be of two types : transitions and transversions. Transitions are the replacement of a purine with other purine and replacement of a pyrimidine with another pyrimidine. Transversions are the replacement of a purine with pyrimidine and replacement of a pyrimidine with the purine. As we know that out of total 64 possible codons, there are 61 coding codons and 3 are stop codons. Let's suppose that the codon is ATG; transition for each base converts it to TAC (purine to purine and pyrimidine to pyrimidine) which means that there are three types of transitions possible for each triplet. Since there are two purines and two pyrimidines, transversions for each purine can be of two types; adenine can be substituted with guanine or cytosine. Thus, there are total six types of transversions possible for each triplet. Total number of base substitution possible for 61 bases = 61 x 3 x 6= 1098. The correct answer is E.
Base substitution is the replacement of a base pair which can be of two types : transitions and transversions. Transitions are the replacement of a purine with other purine and replacement of a pyrimidine with another pyrimidine. Transversions are the replacement of a purine with pyrimidine and replacement of a pyrimidine with the purine. As we know that out of total 64 possible codons, there are 61 coding codons and 3 are stop codons.
Let's suppose that the codon is ATG; transition for each base converts it to TAC (purine to purine and pyrimidine to pyrimidine) which means that there are three types of transitions possible for each triplet. Since there are two purines and two pyrimidines, transversions for each purine can be of two types; adenine can be substituted with guanine or cytosine. Thus, there are total six types of transversions possible for each triplet. Total number of base substitution possible for 61 bases = 61 x 3 x 6= 1098. The correct answer is E.
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