Question

Cortisol is secreted by the adrenal cortex in response to stress. In addition to its function in a stress response, it functions in negative feedback by

• A. Inhibiting hypothalamus to secrete corticotropin releasing hormone or CRH
• B. Inhibiting anterior pituitary's ability to respond to CRH
• C. Inhibiting the epinephrine
• D. Both A and B

Answer 1

The correct option is D Both A and B

• One distinctive feature of hormones whose secretion is regulated through the hypothalamus and pituitary is that they regulate their own secretion through negative feedback inhibition.
• for example, cortisol binds to its receptor on cells in the hypothalamus and adenohypophysis, and has the effect of inhibiting secretion of tropic hormones: in this case, CRH (corticotropin releasing hormone) and ACTH (adrenocorticotropic hormone).
• Less tropic hormone secretion leads to less stimulation of cortisol secretion by cells of the zona fasciculata of the adrenal cortex. Hence, Cortisol is secreted by the adrenal cortex in response to stress. In addition to its function in a stress response, it functions in negative feedback by Inhibiting hypothalamus to secrete corticotropin-releasing hormone or CRH and Inhibiting anterior pituitary's ability to respond to CRH.

So, the correct answer is 'both A and B.