Cortisone, a steroid hormone produced by the adrenal cortex. Introduced in 1948 for its anti-inflammatory effect in the treatment of rheumatoid arthritis, it has been largely replaced by related compounds that do not produce certain undesirable side effects. Cortisone Hormone produced by the cortex of the adrenal glands and essential for carbohydrate, protein and fat metabolism, kidney function and disease resistance. Synthetic cortisone is used to treat adrenal insufficiency, rheumatoid arthritis and other inflammatory diseases and rheumatic fever. So, the correct option is ‘Cortex of adrenal’.