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Question

Cushing's disease is caused due to hypersecretion of


A

Pituitary

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B

Adrenal cortex

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C

Thyroid

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D

Adrenal medulla

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Solution

The correct option is B

Adrenal cortex


The correct option is B:

Explanation of the correct option:

  1. Cushing's disease is a condition due to hypersecretion of mineralocorticoids and which may be due to the formation of tumors(adenoma) in the adrenal cortex.
  2. Cushing's disease is characterized by oversecretion of cortisol, high sodium levels in the blood, abdominal obesity, thin and weak limb muscles, and increased hair growth.
  3. The adrenal gland is a triangular/conical gland, made of two distinct regions an outer cortex, and an inner medulla region. The outer cortex is made up of three-layer that produce three hormones such as; Mineralocorticoids, Glucocorticoids, and Sex corticoids.

Explanation of the incorrect option:

Option A:

Hypersecretion of growth hormone (GH) from the pituitary gland leads to Acromegaly, Gigantism.

Option C:

Hypersecretion (hyperthyroidism) of the thyroid gland leads to Grave's disease (exophthalmic goitre).

Option D:

The adrenal medulla produces two hormones adrenaline (epinephrine) and nor-adrenaline (nor-epinephrine) that function in the body to prepare for an emergency.

Final answer: Cushing's disease is due to the hyper-secretion of the adrenal cortex.


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