Question

Cystic fibrosis is caused due to

• A. Recessive sex-linked gene on X-chromosome
• B. Recessive autosomal gene on chromosome 7
• C. Dominant sex-linked gene on X-chromosome
• D. Dominant autosomal gene on chromosome 11

Answer 1

Answer: (B)

Recessive autosomal gene on chromosome 7

• Cystic fibrosis is an inherited disease.
• It is caused due to the mutation of the cystic fibrosis gene on chromosome 7.
• The cystic fibrosis gene encodes a protein known as the cystic fibrosis transmembrane regulator (CFTR).
• This abnormal CFTR protein in patients with cystic fibrosis leads to disruption of chloride channels on the cells.
  
• It is characterized by the production of abnormal mucus that is excessively thick and sticky.
  
• It affects the secretory glands, lungs, pancreas, liver, intestines, sinuses, and sex organs.