Question

Decline in activity of enzyme hexokinase by glucose 6-phosphate is caused by

• A. Non-competitive inhibition
• B. Competitive inhibition
• C. Allosteric modulator
• D. Denaturation of enzyme

Answer 1

The correct option is C Allosteric modulator

Hexokinase is a regulatory enzyme which catalyses the entry of glucose into glycolytic pathway. The enzyme catalyses the conversion of glucose into glucose-6-phosphate. Hexokinase has high affinity for glucose. the hexokinase is allosterically inhibited by its own product which is glucose-6-phosphate. When the concentration of glucose-6-phosphate increases, it binds with the enzyme at its allosteric site and brings about the conformational change in the enzyme. Due to this enzyme can no longer bind to the glucose and the forward reaction is inhibited. Such type of inhibition is known as feedback inhibition.

Thus, the correct answer is option B.