Question

Decline in the activity of the enzyme hexokinase by Glucose-6-phosphate is caused by

• A. Non-competitive
• B. Competitive modulators
• C. Allosteric modulators
• D. Denaturation of enzymes
• E. Increased by substrate concentration

Answer 1

Answer: (C)

Allosteric modulators

Glucose 6-phosphate acts as an allosteric modulator for hexokinase. Glucose 6-phosphate binds to the regulatory site on the hexokinase which causes conformation changes on the active site of hexokinase and so, the substrate cannot bind to hexokinase. This declines the activity of hexokinase. The increase in glucose-6-phosphate does not cause a decline in activity of hexokinase.

Thus, the correct answer is option C.