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B
Chromosome mutation
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C
Gene modification
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D
Aneuploidy
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Solution
The correct option is D Chromosome mutation A mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements. The gene is the basic physical and functional unit of heredity. It consists of a specific sequence of nucleotides at a given position on a given chromosome that codes for a specific protein. Deletion of certain genes causes chromosome mutation because genes are a sequence of nucleotides at a given position on a given chromosome.