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Advantage of Gene Therapy over Drugs

Describe the ...

Question

Describe the gene therapy procedure for ADA- deficient patient.

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Solution

ADA stands for Adenosine deaminase. The best method to produce gene therapy bone-marrow transplantation at the embryo stage.

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Q. Describe the gene therapy produce for an ADA-deficient patient.

Q. Figure given below depict the procedure for gene therapy. Pick up the disorders for which this technique has been applied successfully.

What is the first step in gene therapy to treat ADA deficiency?

Q. How many of the following statements are true?
I. An ADA deficient patient requires infusion of genetically engineered lymphocytes periodically.
II. There is no need for periodic infusion if the ADA gene is introduced at the early embryonic stage.
III. ADA gene is introduced into lymphocytes by using Ti plasmid.
IV. Gene therapy using retroviral vectors may cause cancers in some patients.
V. Bone marrow transplantation and enzyme replacement therapy are completely curative.

Q. Arrange the following steps of gene therapy for ADA deficiency in the correct sequence.
I) Infection of lymphocytes by genetically engineered retrovirus
II) Culture of lymphocytes
III) Isolation of lymphocytes from ADA deficient patient
IV) Genetically modified lymphocytes are injected back to patient

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Advantage of Gene Therapy over Drugs

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