The main difference between single circulatory systems and double circulatory systems is that in the case of single circulatory systems, blood passes through the heart only once on each circuit around the whole of the blood circulation system of the animal and a double circulatory system, means we have two loops in our body in which blood circulates. One is oxygenated, meaning oxygen rich, and the other is deoxygenated, which means it has little to no oxygen, but a lot of carbon dioxide.
Example of single circulation - found only in fishes.
Example of double circulation - Found in amphibians, reptiles, birds and mammals.