Question

Differentiate between prosthetic group and co-enzyme .

Answer 1

Prosthetic Group vs Coenzyme
Prosthetic group is a type of a helper molecule which is a nonproteinaceous compound that helps enzymes to perform their functions.	Coenzyme is a specific kind of cofactor molecule which is an organic molecule that helps enzymes to catalyze chemical reactions.
Bond with Enzymes
They bind tightly or covalently with enzymes to aid enzymes.	They bind loosely with the active site of the enzyme to help catalytic function.
Composition
Prosthetic groups are metal ions, vitamins, lipids, or sugars.	Coenzymes are vitamins, vitamin derivatives or nucleotides.
Main Function
Prosthetic group mainly provides a structural property to the enzyme.	Coenzyme mainly provides a functional property to the enzyme.
Removal from the Enzyme
Prosthetic groups cannot be easily removed from the enzymes.	Coenzymes can be easily removed from the enzymes.
Examples
Examples include flavin nucleotides and heme.	Examples include AMP, ATP, coenzyme A, FAD, and NAD+, S-adenosyl methionine